Replies to post #100 on BELLUS Health Inc (BLU)

[Power of Emouna]

Still lots hope in near future!

Quote:

“In the RELIEF trial, we observed data that we believe is competitive within the P2X3 class, including the reduction in cough frequency shown in patients with higher cough counts and a low taste effect. While we had hoped to see more response in the lower cough patients, BLU-5937 and other P2X3 antagonists may have the most benefit in patients with a greater disease burden,” said Roberto Bellini, President and Chief Executive Officer of BELLUS Health. “We believe the Phase 2 data support moving BLU-5937 forward into an adaptive Phase 2b trial enriched for higher cough count patients. We expect to begin this trial in the fourth quarter of 2020.”

“Currently, there are no approved treatments for refractory chronic cough, a condition that affects the quality of life of millions of patients globally. BELLUS Health was able to show clinically and statistically meaningful reductions in cough count in patients with higher baseline cough count, which may be the best available clinical indicator of cough hypersensitization via the P2X3 pathway. In addition, BLU-5937’s high selectivity resulted in a favorable tolerability profile with little reported taste disturbance,” said Dr. Jaclyn Smith, Professor of Respiratory Medicine at the University of Manchester in the United Kingdom and an Honorary Consultant at the University Hospital of South Manchester NHS Foundation Trust, and Chair of BELLUS Health’s Clinical Advisory Board. “The RELIEF Phase 2 data set the stage for the further development of BLU-5937 and I look forward to continuing to work on the program.