AbbVie’s product stems partly from a 2006 partnership with Enanta Pharmaceuticals of Watertown, Mass.[#msg-15492225]. The collaboration produced ABT-450, or paritaprevir, which is known as a protease inhibitor and works with other drugs in the regimen to block replication of the hepatitis C virus.
Abbott Labs and now AbbVie have paid $160 million to Enanta in the form of an upfront fee and subsequent research milestone payments, according to Enanta. And AbbVie will pay more if the hepatitis C regimen is approved.
Specifically, ABBV will pay ENTA a $75M milestone for FDA approval, another $75M milestone for EMA approval (expected in early 2015), and a 4-6% tiered royalty on worldwide gross sales of the 3-DAA regimen.