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miljenko

04/07/20 1:45 AM

#230612 RE: DewDiligence #230609

Humabs BioMed (VIR) work (early, 2004) on SARS-CoV-1, where they isolate neutralizing abs binding into conformational changed (activated) Spike-RB S2 domain:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095806/
and in 2015 on MERS-CoV: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547275/
Latest , more sophisticated article in Cell, 2019 (MERS and SARS combination work), https://www.ncbi.nlm.nih.gov/pubmed/30712865

Interesting, they do not have US/EU patent or patent application on SARS/MERS Abs.