Replies to post #229104 on Biotech Values

[bladerunner1717]

I have read somewhere that while the virus is incubating, it will not show positive on the test kits. Is that true? If so, then how far into the manifestations of the virus do you need to be in order to test positive on the test kits? Again, if this is true, then it would seem that people may need to be tested more than once or twice.


Bladerunner

[bladerunner1717]

CDC tells people over 60 with underlying health conditions to stay at home. (Since I have leukemia and asthma, and I'm over 70, I'm not going out.)



HEALTH AND SCIENCE
CDC tells people over 60 or who have chronic illnesses like diabetes to stock up on goods and buckle down for a lengthy stay at home
PUBLISHED MON, MAR 9 20206:15 PM EDTUPDATED 14 MIN AGO
Dawn Kopecki
@DAWN_KOPECKI
Noah Higgins-Dunn
@HIGGINSDUNN
Hannah Miller

KEY POINTS
The CDC is expanding its guidance for people at extreme risk of serious illness, like those over 60 or with underlying health conditions.
Those over the age of 60 should start stocking up on enough groceries and medications to have on hand, the CDC said.
Those at greatest risk of serious illness should stay home as much as possible if COVID-19 comes to their community, the CDC said.
RT: CDC Centers for Disease Control and Prevention (CDC) headquarters in Atlanta, Georgia

Many Americans will be exposed to COVID-19 over the next year or so with many people in the U.S. getting sick, a top CDC official said Monday, recommending that people over 60 and anyone with chronic medical conditions buckle down for a lengthy stay home.

“This virus is capable of spreading easily and sustainably from person to person ... and there’s essentially no immunity against this virus in the population,” Dr. Nancy Messonnier, director of the CDC’s National Center for Immunization and Respiratory Diseases, told reporters on a conference call, citing World Health Organization data that studied more than 70,000 cases in China.

“It’s fair to say that, as the trajectory of the outbreak continues, many people in the United States will at some point in time, either this year or next, be exposed to this virus and there’s a good chance many will become sick,” she said. Most people won’t develop serious symptoms, but 15% to 20% of the people who are exposed to the virus get severely sick, she said.

Of the 70,000 cases WHO scientists looked at, only about 2% were in people younger than 19. The odds of developing COVID-19 increase with age, starting at age 60. It’s especially lethal for people over 80.

“This seems to be a disease that affects adults and most seriously older adults,” she said. “Starting at age 60, there is an increasing risk of disease and the risk increases with age.”

People with diabetes, heart disease, lung disease and other serious underlying conditions are more likely to develop “serious outcomes, including death,” she said.

The CDC is recommending people with underlying conditions or who are over 60 to stock up on medications, household items and groceries to stay at home “for a period of time,” she said. The U.S. government recommended travelers with underlying health conditions avoid taking any cruises anywhere in the world. “We also recommend people at higher risk avoid non-essential travel, such as long plane trips,” she said.


What you need to know about travel insurance as coronavirus spreads
The CDC is recommending that people at higher risk avoid crowds, touching “high-touch” surfaces in public areas and close contact with people who are sick.

“These are the kind of recommendations that I’ve made to my parents ... other staff at CDC are doing the same,” she said.

While the virus is slowing in China where it originated in December, it’s picking up pace across other parts of the world. Italy has the most cases outside of China with more than 9,100 infections, followed by Korea and Iran, which each had more than 7,100 COVID-19 cases as of Monday afternoon, according to data compiled by Johns Hopkins University.

In the U.S., cases erupted over the last week to more than 600 infected and 22 killed, according to John Hopkins University. Almost half of the more than 600 cases in the U.S. are in Washington state and California, with 19 deaths across the U.S.California, Washington and New York, although the virus has now spread to more than 30 states across the U.S.

“During an outbreak with a new virus there is a lot of uncertainty. Our guidelines and recommendations are likely to be interim and subject to change as we learn more,” she said. In South Korea, no one under the age of 30 has died and in Japan, no one under 50 has died, she said. “Data from these countries help us understand the potential risk in the U.S.”

Bladerunner

[biocqr]

Angiotensin and Coronavirus Infection: The Latest as of April 7

https://blogs.sciencemag.org/pipeline/archives/2020/04/07/angiotensin-and-coronavirus-infection-the-latest-as-of-april-7

Recall that the coronavirus itself uses the ACE2 protein as an entry point into cells. One worry has been that the use of antihypertensive drugs (of either class mentioned above) might well cause ACE2 expression to increase, which seems as if it could be a bad idea, providing more targets for the virus to latch on to. But this survey of the literature found little evidence that these expression changes even happen. The animal data that show these effects, they report, tend to be via acute injury models or doses that are much higher than human patients encounter, and there seems to be no good evidence that it happens in humans. So that’s one thing to think about: a big part of the worry about antihypertension drugs may not be even be founded on a real problem.

We also have some clinical data: this preprint from a multicenter team in Wuhan retrospectively evaluates 43 patients with hypertension who were taking drugs in these two classes versus 83 hypertension patients who were not taking ACE inhibitors or ARBs, versus. 125 age- and gender-matched controls without hypertension at all. They also compared hospital admission statistics in general to patients’ medical histories. They first confirmed what others have found, that hypertension itself is a risk factor: the patients admitted for treatment had higher levels of hypertension than the general population, and once admitted those patients had higher death rates and longer hospital stays. But when they looked at the hypertension patients who were taking either ACE inhibitors or ARBs, their numbers were better. They had comparable blood pressure numbers to those taking other drugs, but they were a lower percent of critical patients (9.3% versus 22.9%, near miss on statistical significance) and had a lower death rate (4.7% versus 13.3%). The ACE/ARB cohort also had lower inflammation markers (c-reactive protein and calcitonin). So while the data are noisy, there may be a trend towards protection in those taking angiotensin-targeting drugs. All the more reason to heed the advice not to change therapies for people with hypertension.