Many of the oral agents for HCV are prodrugs. One advantage of starting with a relatively simple parent molecule is that modifying it for oral bioavailability is relatively straightforward. Regards, Dew
p.s. Your earlier link to the abstract did not work because of an iHub bug. Please see #msg-13965884 for details on a workaround for this bug. I keep this info in the iBox atop the main message-board screen for handy reference.