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Whalatane

12/23/19 3:37 PM

#227901 RE: miljenko #227899

M. Re AMRN. so I assume you are referring to Epanova and the STRENGTH trial and are aware of the inclusion criteria for that trial

Inclusion Criteria:
Men or women, ≥18 years of age.
Patient must be on a stable diet and statin* therapy at least 4 weeks prior to randomization (Visit 2) and meet the following criteria:
LDL-C <100 mg/dL
TG level ≥180 and <500 mg/dL and HDL-C <42 mg/dL for men or HDL-C <47 mg/dL for women. ...my emphasis .

Note ..Amarins Reduce It trial did not have an HDL level requirement for inclusion ....so even if STRENGTH shows equal or better RRR in MACE. ..which I doubt ...its based on a far smaller patient population profile .

Higher incidences if diarrhea have always been associated with high doses of EPA/DHA products ...and I expect to that to show up in the STRENGTH data as well ...not to mention the likely hood of higher rates of A Fib since Epanova is not that different from Lovaza.
JMO
Kiwi