Restore the endothelial barrier and then we can judge. Figure 2E below is my favorite DD on the web for those that have not seen it. Left picture is normal barrier, middle is damaged, right is repaired. Had to do a double take first time I saw it. Some want to improve the poop bacteria and some want to get ahead of that issue and maintain the barrier. Difference is in research of "wanting" vs photographic evidence IMO https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652299/
Keep healthy endogenous brain enzymes such as BDNF and the body can maintain sleep health. Journal of Sleep Research from last year article below. Been linked here before of course. Notice the last sentence regarding REM sleep and its role in neuroplasticity. Notice its research in an actual trial designed to measure sleep. Fact is that if the neurons never die, sleep doesn't become an issue.
J Sleep Res. 2018 Feb;27(1):73-77. doi: 10.1111/jsr.12577. Epub 2017 Jun 28. Serum brain-derived neurotrophic factor (BDNF) in sleep-disordered patients: relation to sleep stage N3 and rapid eye movement (REM) sleep across diagnostic entities. Deuschle M1, Schredl M1, Wisch C1, Schilling C1, Gilles M1, Geisel O2, Hellweg R2.
Abstract Experimental and clinical evidence suggests an association between neuroplasticity, brain-derived neurotrophic factor and sleep. We aimed at testing the hypotheses that brain-derived neurotrophic factor is associated with specific aspects of sleep architecture or sleep stages in patients with sleep disorders. We included 35 patients with primary insomnia, 31 patients with restless legs syndrome, 17 patients with idiopathic hypersomnia, 10 patients with narcolepsy and 37 healthy controls. Morning serum brain-derived neurotrophic factor concentrations were measured in patients and controls. In patients, blood sampling was followed by polysomnographic sleep investigation. Low brain-derived neurotrophic factor levels were associated with a low percentage of sleep stage N3 and rapid eye movement sleep across diagnostic entities. However, there was no difference in brain-derived neurotrophic factor levels between diagnostic groups. Our data indicate that serum levels of brain-derived neurotrophic factor, independent of a specific sleep disorder, are related to the proportion of sleep stage N3 and REM sleep. This preliminary observation is in accordance with the assumption that sleep stage N3 is involved in the regulation of neuroplasticity.