GFP, why do you say "It's doubtful that we'll ever get to dose at 800mg BID again with CX-717"? Isn't 800mg about 1% of the heroic dose that caused the histo problem? If they will allow .5% (400-500mg), why not go crazy with the cheeze-whiz and go for the full 1% dose? We're talking one-one hundredth of the "heroic" dose that caused the problem.
I'm no FDA genious, but why is everybody so worried about problems seen from a hyper-overdose? Why would anybody in their right mind think CX-717 should be scrapped? I have posted this question a number of times before, and nobody will answer it.
MF4
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