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InTheTrenches

07/15/19 3:20 PM

#225576 RE: DewDiligence #225574

The scientific literature bolsters NTRP's claim that Bryostatin upregulates PKC-e, which affects BDNF, IGF and NGF. These CNS pathways restore synpapses, clear Amyloid-Beta and Tau, and are neuro-protective.

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DewDiligence

09/09/19 8:56 AM

#226120 RE: DewDiligence #225574

NTRP fails phase-2 trial in AD:

https://www.prnewswire.com/news-releases/neurotrope-announces-top-line-results-from-confirmatory-phase-2-study-of-bryostatin-1-in-moderate-to-severe-alzheimers-disease-300913655.html

Neurotrope…today announced that its confirmatory Phase 2 study of Bryostatin-1 in moderate to severe AD did not achieve statistical significance on the primary endpoint, which was change from baseline to Week 13 in the Severe Impairment Battery (SIB) total score.