Replies to post #225484 on Biotech Values

[biotech jim]

Thanks for that, hmpa.

This provides for FGF21 fusion proteins, but in the text I could not find anything regarding coincident Glp-1 agonism. I will continue my search. THe concept is solid, as Glp1 agonists are now being investigated in NASH.

This has the potential to have both metabolic effects directly via the Glp1R, and then fibrosis resolution via FGF21 agonism. Pretty difficult to obtain sufficient potency and slectivity for both Rs in a single polypeptide chain.