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Bickema

02/19/19 9:27 AM

#223663 RE: DewDiligence #223659

Ocaliva (OCA) is an FXR agonist. I’ve posted on numerous occasions that I don’t think Ocaliva has what it takes to garner big sales, due to its side-effect profile, and the top-line REGENERATE data are consistent with such a viewpoint



Good news for ENTA? Can they avoid the side effects you speak of?

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DewDiligence

02/19/19 11:21 AM

#223666 RE: DewDiligence #223659

Summary of ICPT’s phase-3 data—including the sky-high pruritus rate:

http://www.evaluate.com/vantage/articles/news/trial-results/intercepts-nash-hopes-rest-ocalivas-borderline-hit
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DewDiligence

02/19/19 6:11 PM

#223668 RE: DewDiligence #223659

ICPT closes +6% (after having been much higher in early trading).