Replies to post #37146 on Biotech Values

[dewophile]

rib has shown antagonism with pyrimidine analogues in HIV

Baba, M., R. Pauwels, J. Balzarini, P. Herdewijn, E. De Clercq, and J. Desmyter. 1987. Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro. Antimicrob. Agents Chemother. 31:1613-1617.[Abstract/Free Full Text]

Vogt, M. W., K. L. Hartshorn, P. A. Furman, T. C. Chou, J. A. Fyfe, L. A. Coleman, C. Crumpacker, R. T. Schooley, and M. S. Hirsch. 1987. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science 235:1376-1379.[Abstract/Free Full Text]

We'll soon find out if rib and nm-283 should or shouldn't be given together when moves to phase III