Widespread screening is not currently feasible given that a definitive diagnosis of NASH can only be made through identification of the characteristic histopathologic pattern on liver biopsy. While liver biopsy remains the gold-standard, its disadvantages are well known,” Saumya Jayakumar, MD, from the University of California in San Diego, and colleagues wrote. “There is a pressing unmet medical need for reliable and accurate noninvasive tools to evaluate steatosis and fibrosis in patients with NASH, and to monitor response to treatment.”