Replies to post #36668 on Biotech Values

[gofishmarko]

>> I think the concept of avoiding low HDL is pretty well validated. Whether the benefit increases linearly with increasing HDL, or if there is a threshold is probably up for debate. <<

This paper suggests a benefit for very high HDL re: all-cause mortality. ( This doesn't prove that raising HDL artificially provides such a benefit , however. ):


The inverse relationship between serum high-density lipoprotein cholesterol level and all-cause mortality in a 9.6-year follow-up study in the Japanese general population

OKAMURA Tomonori (1) ; HAYAKAWA Takehito (2) ; KADOWAKI Takashi (1) ; KITA Yoshikuni (1) ; OKAYAMA Akira (3) ; UESHIMA Hirotsugu (1) ;

(1) Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu City, Shiga 520-2192, JAPON
(2) Department of Public Health, Shimane University School of Medicine, Shimane, JAPON
(3) Department of Preventive Cardiology, National Cardiovascular Center, Osaka, JAPON
NIPPON DATA90 Research Group, JAPON

In populations with higher high-density lipoprotein cholesterol (HDL-C) levels and lower coronary mortality than Western populations, such as in Japan, the beneficial effect of HDL-C on all-cause mortality may be different. Furthermore, prior studies have not focused on very high level of HDL-C. A total of 7175 community Japanese residents without a past history of cardiovascular disease in 300 randomly selected districts were followed for 9.6 years. During follow-up, there were 636 deaths. The multivariate adjusted hazard ratio (HR) of HDL-C for all-cause or cause-specific mortality was calculated using a Cox proportional hazard model adjusted for other cardiovascular risk factors. The all-cause mortality suggested an inverse, graded relation with HDL-C categories; HR for the very high HDL-C category (≥ 1.82 mmol/L), compared with the reference group (1.04-1.55 mmol/L), was 0.73 (95% confidence interval, C.I., 0.50-1.06) for men, 0.63 (95% C.I., 0.41-0.94) for women and 0.70 (95% C.I., 0.53-0.93) when men and women were combined. Serum HDL-C as a continuous variable showed a significant inverse association with all-cause mortality. The cardiovascular mortality indicated a non-significant but inverse graded relation with HDL-C categories. As in the many Western populations, serum HDL-C levels were inversely associated with all-cause mortality in the Japanese general population.

Revue / Journal Title

Atherosclerosis (Atherosclerosis) ISSN 0021-9150
Source / Source

2006, vol. 184, no1, pp. 143-150 [8 page(s) (article)] (32 ref.)