keep your eye on riboswitch- not sure how this will evolve but these seem to fill a void in the cellular machinery- small molecule sensors. The story with siRNA was how quickly it went from discovery to commercial- only discovered late last century IIRC.
How has the safety looked (no pun intended)? Wasn't there a European trial a few years back that set back gene therapy because of leukemia in some patients?
It sure seems like a lot of people are working on wet AMD, does anyone know any promising dry AMD candidates (outside of treatments to stop progression to wet)?