Axaron is extremely excited about the potential for AX200, as work in pre-clinical models has shown that the drug has multiple modes-of-action and is not only capable of protecting brain cells from damage occurring during the acute phase of stroke, but also improves the functional performance thereafter."
All of the neuroprotectants did well in animal studies that is why they went into humans. It is my feeling that the brains of lower species allow the neuroprotectant to get around the clot so they can protect the brain tissue even though the blood can't get the oxygen where it has to go. In humans the neuroprotectant can't get around the clot so they can't do their job. When the toilet is stuffed you need a plunger to unblock it, otherwise it overflows.
A neuroprotectant may work but first you have to find a way to bust the clot without causing bleeding. I think that desmonteplase may be the clot buster
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