Traders start with a huge problem, which is called trading. Studies suggest the stocks they buy tend to lag the market and those they sell tend to outperform. Put succinctly: "The more You Trade, The More You Lose."
Each trade introduces a bit of friction from spreads, commissions and taxes, plus most traders simply end up on the losing side due to human shortcomings. Traders, even in highly liquid listed stocks are wrong about 53% of the time according to studies. OTC stocks like RNVA are especially illiquid.
If you know what you're buying (read and understand the filings) and you like Rennova (which is most unlikely) then you're probably best off buying and holding.
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