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Titan V

04/17/18 4:49 PM

#218557 RE: DewDiligence #218556

Any thoughts on CATB in general Dew? They had decent p2 data and their DMD drug is said to be able to target 86% of DMD mutations vs much lower % for SRPT. They also have a collaboration with SRPT. Wondering if they are trimming staff for a sale. They are low on cash but haven’t raised for some time.

Titan V

04/18/18 4:18 PM

#218572 RE: DewDiligence #218556

CATB closes +13% from yesterday’s AH low upon the layoff news.

The line in bold from yesterday’s PR stood out to me:

Edasalonexent is being developed as a potential disease-modifying therapy for all patients affected by DMD, regardless of their underlying mutation. In the Phase 2 MoveDMD trial and open-label extension, edasalonexent has demonstrated consistent and sustained slowing of disease progression in boys with DMD through more than a year of treatment compared to the off-treatment control period. No evidence of side effects or safety issues common with the current DMD standard of care have been observed after more than 37 patient-years of exposure to edasalonexent. Catabasis is preparing for a single global Phase 3 trial to evaluate the efficacy and safety of edasalonexent for registration purposes, dependent on raising capital.


Haven’t seen a company say they may start a phase 3 depending on capital raise. I am curious if I am reading into it too much or if they are selling the company and used the vague language intentionally.