Presenter matters when APC is targeted. One can block all CD47 on tumors resulting in little response. I think Lm is the best presenter, Neon knows it and is working on delivery.
Lm-19 & Lm-20, targeting 19 non-immunogenic and 20 immunogenic NSMs respectively. The ability of Lm-19 and Lm-20 to control MC38 tumor growth was evaluated in C57BL/6J mice. We found that both Lm-19 & Lm-20 led to an accumulation of neoantigen-specific CD8+ TILs and significantly slowed tumor growth.
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