Replies to post #199 on ProMIS Neurosciences Inc (PMN)

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What’s with the volume today

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ProMIS Neurosciences Announces Appointment of Ernest Bush as Head of Pharmacology/Toxicology and Russell Blacher as Head of Manufacturing

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Both new appointees bring over 30 years of successful drug development experience
TORONTO, Ontario and CAMBRIDGE, Massachusetts – April 3, 2018 – ProMIS Neurosciences, a company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced the appointment of Ernest D. Bush to the position of Head of Pharmacology/Toxicology and Russell Blacher to the position of Head of Manufacturing. These positions report to both Gene Williams, Executive Chairman and Elliot Goldstein, CEO of ProMIS Neurosciences. Dr. Bush and Mr. Blacher will support the design and execution of key late preclinical activities required for clinical trial initiation of lead therapeutic candidate, PMN310.
“We are pleased to welcome Russ Blacher and Ernie Bush to the ProMIS senior team. Both Ernie and Russ bring broad and rich experience and expertise in two critical areas of drug development: product safety/toxicology and manufacturing, respectively. Their appointments add significant value to the ProMIS team in preparing for the 2019 anticipated clinical trial initiation of PMN310, our lead program for Alzheimer’s disease, and for planned regulatory submissions,” said ProMIS President and CEO, Dr. Elliot Goldstein. “We are delighted to have Russ and Ernie join the team as we advance our Alzheimer’s program selectively targeting toxic oligomers of amyloid beta, known to be a root cause of Alzheimer’s.”
About Ernest D. Bush, PhD.
Dr. Bush has 35 years of experience working in the field of biomedical R&D, driving development of innovative therapies for treatment of human diseases. He has served as a consultant in non-clinical development providing advice and insight into IND enabling programs, pre-clinical data-set analysis for due diligence and prioritization of investment decisions, and evaluation and audits of GLP bioanalytical and toxicology facilities and studies. In recent years, Dr. Bush has served as Chief Scientific Officer at Akashi Therapeutics, Inc., providing expertise to the development of drugs in Duchene Muscular Dystrophy. In previous positions, Dr. Bush worked as Senior Research Director and Head of Non-Clinical Drug Safety at Hoffmann-La Roche, Inc. where among other duties he led the assembly and review of preclinical data packages for all potential in-licensing and acquisition drug candidates and companies. He has utilized this experience to help small pharmaceutical companies and non-profit patient advocacy organizations plan and execute strategies to move them forward expeditiously and cost-effectively. Dr. Bush received his PhD. in Medicinal Chemistry from the University of Washington, and an MS in Chemistry and a BA in General Sciences from the University of Oregon.
About Russell Blacher.
Mr. Blacher is Principal and founder of Biopharmaceutical Development Consulting and is an experienced research and development professional for biologic drug compounds. He has more than 30 years of experience in bridging the gap between research and development programs in a variety of corporate environments including virtual biotech start-ups and big pharma. Mr. Blacher has successfully developed a variety of drug candidates and advanced them into clinical trials in both the U.S. and Europe and has actively participated in the programs of several currently marketed biopharmaceutical products including: human insulin (Humulin®), Interferon Alpha (Roferon®), Interleukin-2 (Proleukin®), anti-CD11a (Raptiva®) and anti-EGFR (Vectibix®). He is knowledgeable in all phases of protein/antibody therapeutic drug development including creation of cell lines, upstream and downstream manufacturing, analytical methods development and formulation and is experienced in managing multiple outsourced contract research and manufacturing organizations, quality and compliance programs and is current in Good Manufacturing Practices. He has also authored numerous Chemistry, Manufacturing, Controls sections for regulatory submissions, holds several patents and published more than 50 scientific papers. Mr. Blacher earned his BA in Biochemistry from Thomas A. Edison State College, NJ.
About ProMIS Neurosciences, Inc.
ProMIS Neurosciences is a development stage biotechnology company focused on discovering and developing precision medicine therapeutics to treat neurodegenerative diseases, in particular, Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). The Company’s proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform—ProMIS and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics and specific companion diagnostics for AD and ALS. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN.TO, and on the OTCQB Venture Market under the symbol ARFXF.
For further information please consult the Company’s website at: www.promisneurosciences.com
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For Investor Relations please contact:
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Nicholas Rigopulos, President
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Dr. Elliot Goldstein
President and Chief Executive Officer, ProMIS Neurosciences Inc.
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This announcement contains “forward-looking statements” within the meaning of applicable securities laws. Forward-looking statements are statements that are not historical facts; they are generally, but not always, identified by the words “expects”, “plans”, “anticipates”, believes”, “intends”, “estimates”, “projects”, “aims”, “potential”, “goal”, “objective”, “prospective”, and similar expressions, or that events or conditions “will”, “would”, “may”, “can”, “possibly”, “could” or “should” occur. Forward-looking statements are based on the beliefs, estimates and opinions of the Company’s management on the date the statements are made and they involve a number of risks and uncertainties. Consequently, there can be no assurances that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Except as required by the securities disclosure laws and regulations applicable to the Company, the Company undertakes no obligation to update these forward-looking statements if management’s beliefs, estimates or opinions, or other factors, should change.
Neither the TSX nor the OTCQB has approved or disapproved of the contents of this press release.

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PROMIS NEUROSCIENCES CLOSES $7.2 MILLION PRIVATE PLACEMENT
TORONTO, Ontario and CAMBRIDGE, Massachusetts–May 1, 2018– ProMIS Neurosciences Inc. (TSX:PMN; OTCQB:ARFXF) is pleased to announce that it closed yesterday a private placement of 19,306,668 Units at the price of CDN$0.375 per Unit for gross proceeds of approximately CDN$ 7,240,000.
“We are pleased to close another successful financing”, said Executive Chairman Gene Williams. “This will allow us to continue moving full speed ahead with our lead program PMN310, which selectively targets the toxic oligomers of amyloid beta, a root cause of Alzheimer’s disease. We will also be able to accelerate our development of a broad portfolio of antibodies that selectively target different toxic oligomers including Alpha synuclein, TDP43, Tau and SOD1 in other neurodegenerative diseases, capitalizing on our unique and valuable technology platform.”
Each Unit consisted of one ProMIS common share and one-half of a ProMIS share purchase warrant. Each warrant will entitle the holder thereof to purchase one ProMIS common share at an exercise price of CDN$0.48 at any time for five years, subject to earlier expiry on 30 days notice if, at any time after four months from closing, the twenty-day volume-weighted average trading price of ProMIS’ common shares is greater than CDN$1.00.
ProMIS will compensate finders in respect of a portion of the non-US subscribers through 7% cash fees and a total of 339,360 finder warrants having the same terms as the Unit warrants. Noble Capital Markets, Inc., which acted as placement agent for subscribers in the United States, will receive a cash commission equal to 7% of the gross proceeds placed with its US subscribers and will be issued compensation warrants to purchase up to 215,871 common shares for a period of five years at an exercise price of CDN$0.48 per share.
Net proceeds from the private placement will be used for working capital and general corporate purposes.
All securities issued in connection with the private placement are subject to a four month hold period under applicable provincial securities laws in Canada.
This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of the securities, in any state in which such offer, solicitation or sale would be unlawful. The securities issued, or to be issued, under the private placement have not been, and will not be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.
About ProMIS Neurosciences Inc.
ProMIS Neurosciences is a development stage biotechnology company focused on discovering and developing precision medicine therapeutics to treat neurodegenerative diseases, in particular Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). The Company’s proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics and specific companion diagnostics for AD and ALS. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN.TO, and on the OTCQB Venture Market under the symbol ARFXF.
For further information please consult the Company’s website at: www.promisneurosciences.com
Follow us on Twitter
Like us on LinkedIn
For media inquiries, please contact:
David Schull
RussoPartners/LLC
[e-mail]
Tel. [phone]
For Investor Relations please contact:
Alpine Equity Advisors
Nicholas Rigopulos, President
[e-mail]
Tel. [phone]
Dr. Elliot Goldstein
President and Chief Executive Officer, ProMIS Neurosciences Inc.
Tel. [phone]
[e-mail]