that statement is ludicrous. MANF's value is crescendoing into an S curve. Every time a university, institute, or other company verifies a part of the MANF story, it grows in value, and as you can tell the amount of research being done is exploding. results are lagging indicators of interest, and predictive indicators of value along with many other things.
u are not wrong to say human trials is a key threshold
but it is incredible that you can repeat that proof of the key method of delivery of a large protein across the BBB that's almost identical to MANF does not enhance the programs value. What would MANF be worth if CED didn't work, but MANF was worth nothing? Would it be worth negative less than nothing lol