Replies to post #217262 on Biotech Values

[DewDiligence]

ARPO sells 13.44M* shares @$3.85—a 4% discount to yesterday’s close:

https://finance.yahoo.com/news/aerpio-pharmaceuticals-announces-uplisting-nasdaq-131800279.html

*Assuming exercise of underwriter’s option.

[DewDiligence]

ARPO doesn't seem to have panned out—at least not yet.

[DewDiligence]

ARPO -65%/PM on failed phase-2b in diabetic retinopathy:

https://finance.yahoo.com/news/aerpio-pharmaceuticals-announces-results-time-110000579.html

Administration of AKB-9778 twice daily did not meet the study’s primary endpoint of the percentage of patients with an improvement of two or more steps in the study eye [i.e. the more advanced eye of each patient’s two eyes] diabetic retinopathy severity score (DRSS) compared to placebo. The percentage of patients achieving this endpoint for AKB-9779 twice daily (BID) and placebo were 9.6% and 3.8%, respectively (p=0.270).

In all qualified eyes (i.e., study eyes and fellow eyes [i.e. the second eye in patients who had qualifying disease in both eyes] that met the inclusion/exclusion criteria), the percentage of eyes achieving this endpoint was 8.6% and 2.7%, for AKB-9778 BID and placebo, respectively (p=0.158).

The rates of progression to sight-threatening complications, including diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR), during the 48-week treatment period were similar between treatment groups.