Oh, The GALERA trial is growing more hair. Thanks, cabel, should have checked clinicaltrials.gov by myself (I blame overt excitement and need to get my salt bath like now!)
Some OM trials exclude the use of IMRT method of radiation, some don't. GALERA's may the the first that specifies it exclusively. Modern boys and girls over there.
IMRT is more accurate in targeting tumors and hence radiates healthy tissue less than traditional radiation treatment. Also, in IMRT radiation doses do vary in intensity and the subjects may end up averaging less radiation over time.
GALERA says 60 Gy over 6 to 7 weeks, minimum. Traditional is about 70 Gy over 7 weeks. Notice also specific 'delivered to the tumor'. In studies accepting or sticking only to traditional radiation treatment (like in IPIX trial) you usually see 'delivered to oral cavity'.
Next, guess if your find makes the results more comparable or less comparable?
I guess you will guess right :)
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