Punit was the political major guy with hardly any experience, O'Connor is a lawyer that has proven capable of making deals. The one most important to Oncosec is the one he made between Merck and Advaxis, to utilize Keytruda in a combination with KEYNOTE-046. However, other different studies were being conducted at the same time and things got somewhat backed up, which of course in turn delays cost money. In addition one of their P3 study for testing a type of brain cancer failed. https://www.fool.com/investing/2016/12/15/celldex-therapeutics-incs-biggest-failure-in-2016.aspx
I would imagine this time will be different, since he basically needs to only focus on one major study, which again is with Keytruda, and concentrate the resources on getting the best deal possible from Merck. We all learn from the past.