Replies to post #213861 on Biotech Values

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FGEN > HIF Biology and HIF PHI MOA

h/t @mjtwins

https://t.co/nXKPIzAB7c

Executive summary –

HIF Biology and HIF PHI MOA

The HIF feedback loop is critical for erythropoiesis. This loop is broken in anemia in CKD.

The Erythropoietic response stimulated by HIF-PHI:

• Is achieved with physiological levels of endogenous ESAs

• Is a limited response that allows for robust HIF induced erythropoiesis

• Is intermittent and transient allowing the FIF system to reset and therefore avoiding risk of increased dose requirement over time

• Overcomes the erythropoiesis-suppressive effects of inflammation seen in many patients with CKD

• Down regulates hepcidin thereby promoting iron bioavailability