You keep saying that bavi is a clumsy molecule. Would BBs be better in your opinion and if so why do you think they are not choosing to get it out there.
BB's will not change the "elephant in the room" (Endogenous Protein Cross Reactivity), IMO.
Chemo produces more competition for anti-ps and thus the laws of diminishing returns. What needs to happen is a reduction in receptor site competition. In one such theory, statins would eliminate "marginal" competition, IMO.
The question is how much is marginal, and what therapeutic significance would be achieved?