Replies to post #27338 on Ayala Pharmaceuticals Inc (fka ADXS)

[ignatiusrielly35]

GOG designed the trials. Do you really think they are in the business of trying to fool the market?

[Traderbx]

Another word for control Arm is "placebo group".... adding placebo group costs more money...

Also, in case of the GOG trail, statistics were already know , so no need for placebo group...

Also, in case of phase 1-2 An*l cancer, it has 100% complete response... so why do you need a control arm (placebo)? 100% is as good as it gets...


Also, in case of H&N, 100% complete response (all 8 out of 8 patients cured of throat cancer)... so why waste money and time in placebo unless FDA required?

[DewDiligence]

Delaying the length of time it takes for investors to find out the drug isn't efficacious?

A cynic might say that delaying the results from the first randomized controlled trial for as long as ADXS has done with AIM2CERV enables management to string investors along for several years while insiders benefit personally.

ADXS could have run its first phase-3 trial in the metastatic setting, where results would have been available much sooner than the results from AIM2CERV.

This is not a novel concept. There are certainly some biotech companies who have played such a game.

[Crcook]

Lifter, I think he real reason has to do with obtaining participants for these early Phase 1 and 2 trials---who wants to sign up to do trials with an unknown, upstart baby-bio (that's constantly being bashed on its own message boards)that has a 33-50% chance of only getting a placebo in the first place????



GLTAL's