Replies to post #387 on SurModics Inc (SRDX)

[DewDiligence]

>I do not have great expectations regarding siRNA strategies for AMD... This bias, and it is a bias not a strong negative feeling, comes from my experience with siRNA in cell cultures… However, data will trump my intuition every time.<

I think these results for Sirna-027 are promising. Note that the VA readings were taken 2 months and 3 months after a single intravitreal injection:

#msg-12579143
#msg-12570919

Dew

[aslan2772]

" siRNA in cell cultures (i.e. I have been able to reduce message levels, but usually only to about 50-70% of the pre-treatment levels)... "

This is not uncommon and we sometimes see it in our lab as well. I am also concerned about how the FDA will handle the issue of "off-target" effects of siRNA, which also appear to be fairly common, difficult to predict, and usually hidden (ie genome-wide expression profiling is needed to rule it out).