The fact that sepsis-induced DIc has both distinct antiinflammatory as well as pro-thrombotic mechanisims bodes well for atryn. Remember, heparin has been (and is still used by many) to address the prothrombotic features of the syndrome. results have been mixed with heparin. the antinflammatory features of sepsis-induced DIC specifically may be addressed by atryn to some degree, which is distinct from heparin and may separate these two products clinically. Another huge advantage for Atryn is that it potentiates endogenous heparin already present in circulation, so is self-limiting in that in an unbound form has no direct anticoagulant properties (whereas heparin has a tight therapeutic window defined by a narrow PTT, above which one sees hemmorrhagic complications (and remember, DIC is also paradoxically associated with hemorrhagic complications from depletion of factors following consumptive coagulopathy (basically using up of clotting factores by the disseminated microthromboses that then result in depletion of factors and hemmorrhage)..this duality makes the condition very hard to treat with true blodo thinners)
so there are a number of distinctions to AT III that make it unique and (potentially) more ideal than heparin in this context
adn remember..ATII is notably depleted in DIC, so there is a sound rationale for physiological replacement
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