Replies to post #1021 on TG Therapeutics Inc (TGTX)

[Android 2-73]

i think they play an equally important role.

it appears to be that they supports one another. Depending on the phenotype, some B cells facilitate the development of T cells while T Cells influence B cells to to support the T cells creating a loop with positive anti-inflammatory affects. So you would be correct to say that leaving some t cells in tact would be helpful as that should lead to a longer lasting affect due to this feedback loop.

B cell depletion while leaving some t cells in tact should in theory reduce symptoms while the t cells polarize these b cells to help foster development of more t cells, thus able to continually fight infection with reduced symptoms.

"While accumulating evidence suggests that antigen-activated B cells substantially contribute to the development and progression of MS, the role of naïve B cells is more likely to be regulatory in nature. In this regard, it has been demonstrated that activated and memory B cells in patients with MS produce proinflammatory cytokines and foster development of Th17 cells, while unactivated, naïve B cells predominantly release regulatory IL-10. Reflecting the same dichotomy, anti-CD20 treatment was found to exacerbate EAE in a setting in which B cells were not activated, whereas depletion of activated B cells was associated with clinical benefit"

"Some B cells also have anti-inflammatory properties producing regulatory cytokines and facilitating development and maintenance of other immunomodulatory immune cells, such as regulatory T cells. Reciprocally, differentiated T cells influence T cell polarizing B cell properties establishing a positive feedback loop of joint pro- or anti-inflammatory B and T cell developments. Further, under the control of activated T helper cells, antigen-primed B cells can switch immunoglobulin isotype, terminally commit to the plasma cell pathway or enter the germinal center reaction to memory B Cell development. Taken together, B cells and T cells thus closely support one another to participate in the pathogenesis of MS in an inflammatory but also in a regulatory manner."




Cooperation of B cells and T cells in the pathogenesis of multiple sclerosis.

Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges