Why is M230 an Fc trimer? On a recent webcast, CW explained that MNTA experimented with polymers containing fewer and more copies of the Fc receptor, but three copies gave the desired binding affinity for autoimmune indications.
Because other immunosuppressive therapies for autoimmunity increase risk of infection, the Momenta team administered the trimer to rodents and monkeys housed under non-sterile conditions.
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