Replies to post #287124 on Avid Bioservices Inc (CDMO)

[chevalblanc-47]

reads well, danke schön Hutschi

kind regards
danny

[patientlywaiting]

Here's a translate for you..........

https://translate.google.com/translate?hl=en&sl=de&u=http://www.spiegel.de/gesundheit/diagnose/liquid-biopsy-den-krebs-durchs-blut-aufspueren-a-1036738.html&prev=search


Medical innovation
to cancer diagnosis reaches a drop of blood

Detect cancer cells quickly and directly in the blood? This promises a new method called Liquid Biopsy. It could revolutionize diagnosis and therapy.

From Christian Heinrich
Proben: Krebs-Erbgut lässt sich im Blut aufspüren
DPA
Samples: Cancer genetic material can be detected in the blood
Sunday, 14.06.2015 19:32 To press Rights of use Feedback Reply with quote
Show me your blood and I'll tell you if you have cancer. This is one of the great promises of a new method of diagnosis, the enormous potential of which has led to the emergence of cancer doctors in the last few months. Liquid biopsy (liquid biopsy) is the technique. It makes it possible to detect tiny sections of the mutated hereditary material of cancer cells in the blood.


There is a simple explanation for why such DNA fragments circulate: "In a growing tumor, cells are always dying and getting into the blood, especially when they form or have their own blood vessels," says Ulrich Keilholz, director of the Charité Comprehensive Cancer Center in Berlin. "There are even some intact tumor cells in the blood in most cancers."

This has been known for a long time, and the beginnings of the Liquid Biopsy also date back to the nineties. But modern analysis methods, which have become significantly more powerful, now show how far Biopsy can promote cancer medicine.

Instead of taking blood only

To date, the procedure has been particularly successful in the more precise diagnosis of tumors, which doctors already know. "In some types of lung cancer, the tumor is such that you can not get there safely with a needle and get a sample," says Klaus Pantel, director of the Institute of Tumorbiology at the University Hospital Hamburg-Eppendorf (UKE) and pioneer in the field of Liquid Biopsy .


Such samples, however, are becoming increasingly important because the tumor geneoma can be analyzed. It provides important information for the best treatment options. More and more drugs attack the tumor with its genetic profile: this allows a more effective therapy with fewer side effects.

The diagnosis by Liquid Biopsy is so reliable that the first tests are already on the market. The German biotechnology company Qiagen, together with the pharmaceutical company AstraZeneca, received the first approval worldwide for a blood test, in which circulating tumor DNA from humans with lung cancer is examined for specific mutations. The mutations tested in the test are the starting point of a drug from AstraZeneca. According to Qiagen, numerous other tests are under development by Liquid Biopsy for cancer therapeutics.

In the future, the method could also help to control the course of the therapy. "One can not sting a patient every few days with a needle to take samples from tumor tissue, which is too risky for many tumor types for a variety of reasons," says Keilholz. On the basis of the amount of cells and the DNA in the blood and its change, however, one could possibly say whether and how a therapy works. "This enables us to quickly identify the reasons for the resistance to therapy and to provide valuable time for many patients," Keilholz explains.

Early discover, better treat

And then there is the great vision of a cancer screening: a blood test that everyone can make from a certain age and which includes all important tumor types. Anyone who has lung cancer or breast cancer can be so early on and thus would have much better healing chances.

"The older we are, the more mutations we develop in our cells, but most of them are harmless and do not lead to cancer, Even if they can also be found on tumor cells. " Accordingly, there would often be false positive results in such tests. That is, there are indications of cancer, although everything is in order. On the contrary, the traces in the blood are so small in some types of tumor that they can not be detected.

Despite such hurdles, Liquid Biopsy should also be used in other medical areas. Already today, there is a blood test for pregnant women, in which chromosomal disorders such as trisomy 21 can be diagnosed by means of DNA fragments of the unborn child circulating in the mother's blood.

And the genetic causes are increasingly understood more and more by suffering. This will open up new fields of application for Liquid Biopsy - the immense progress in genetics can also be advances in liquid biopsy.

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To the author

Christian Heinrich
Christian Heinrich went to his medical studies at the German School of Journalism. Since 2010 he has been working as a freelance journalist in Hamburg. In addition to health and science, he also writes about business and society, travel and education.
Homepage of the author

[Braumeister]

Too bad the article does not mention PPHM.