"even the much larger avastin was shown to do this as was published in Retina."
I have a different slant on this issue, and I do not agree with that interpretation. From the figures in the paper you are thinking of (the Shahar et. al. study in Rabbits with 2.5 mg Avastin/eye, published in Retina 2006 Mar;26(3):262-9, right?) there was some evidence of initial retinal penetration using a very high sensitivity approach, but the penetration was relatively poor and short-lived. Avastin may work, but IMHO not because it can penetrate the retina well. Perhaps mopping up excess VEGF in the vitreous lowers VEGF levels in the retina?
"DNA originally stated that avastin theoretically does not penetrate."
Genentech studied a different full-length antibody (presumably antibodies of the same Ig class have a similar tissue distribution - granted this assumption may or may not be correct) and did not see evidence of full retinal penetration using standard immunohistochemical techniques. I still think their conclusion is basically correct though, in that full-length antibodies do not efficiently penetrate the retina.
P.S. I tend to cut back on coffee/tea myself from time to time. Keeps me grounded ;)_
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