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Replies to post #286282 on Avid Bioservices Inc (CDMO)
While all exosomes, whether from tumor cells or normal cells, share membrane epitopes found on the parent cell membrane, an exhaustive series of experiments revealed that, in contrast to exosomes secreted from normal cells, only tumor cell-derived exosomes express the membrane phospholipid, phosphatidylserine (PS), in the outer leaflet of the particle membrane (TABLE 2). Based on unequivocal data showing that PS is a unique signature of tumor exosomes, the inventors propose a biomarker-based discovery platform for the screening and detection of exosomal PS signatures in patient blood that will be diagnostic for cancer, a prognostic marker for stage of disease and a predictive marker for response to therapy and disease recurrence.
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