The costs to sell even one gram of legal cannabis aren't necessarily prohibitive, but it's enough to prevent OTC companies from operating in this space.
For example. This is a list of requirements for a medical cannabis license in the state of Illinois.
Projected start-up costs
Dispensary fees:
Non-refundable application fee for a dispensary permit: $5,000
Once issued a permit, $30,000 permit fee for the first year
Annual permit renewal: $100,000
Applicants were required to demonstrate $400,000 in liquid assets and $50,000 in escrow
Cultivation fees:
Non-refundable application fee for a cultivation permit: $25,000
Once issued a permit, $200,000 permit fee for the first year
Annual permit renewal: $100,000
Applicants were required to demonstrate $500,000 in liquid assets and a $2,000,000 bond to the Department of Agriculture