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DewDiligence

10/20/16 10:02 AM

#205368 RE: DewDiligence #205362

ADXS/MRK—Dosing during the phase-2 portion of the study:

https://www.clinicaltrials.gov/ct2/show/NCT02325557

Patients will receive ADXS31-142 and pembrolizumab [Keytruda] in combination. Dosing of ADXS31-142 will start at one dose level less than appropriate in Part A in combination with 200 mg of pembrolizumab. Dosing of ADXS31-142 will be escalated if appropriate.