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DewDiligence

01/31/17 5:03 PM

#208604 RE: DewDiligence #204733

CATB -69%/AH on failed trial in DMD:

http://finance.yahoo.com/news/catabasis-pharmaceuticals-announces-top-line-210100111.html

The primary efficacy end point of average change from baseline to week 12 in the MRI T2 composite measure of lower leg muscles for the pooled edasalonexent treatment groups of 67 mg/kg/day and 100 mg/kg/day compared to placebo was not met (0.37 milliseconds for the pooled edasalonexent treatment groups versus 0.47 milliseconds for placebo, a smaller increase in MRI T2 correlating with less muscle inflammation). The edasalonexent 100 mg/kg/day treatment group consistently showed numerical improvement versus placebo across multiple measures although the changes were not statistically significant.