Replies to post #204224 on Biotech Values

[Titan V]

Great to know additional causes of non-response. Thanks for sharing biocqr.

[biocqr]

adenosine A2a receptor > Caffeine and its analogues revert memory deficits by normalizing stress responses in the brain

A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals.

http://english.inserm.fr/press-area/caffeine-and-its-analogues-revert-memory-deficits-by-normalizing-stress-responses-in-the-brain

“In elderly people, we know there is an increase of stress hormones that have an impact on memory. Our work supports the view that the procognitive effects of A2AR antagonists, namely caffeine, observed in Alzheimer’s and age-related cognitive impairments may rely on this ability to counteract the loss of stress controlling mechanisms that occurs upon aging”

This is important not only to understand the fundamental changes that occur upon aging, but it also identifies the dysfunctions of the adenosine A2A receptor as a key player in triggering these changes. And a very appealing therapeutic target” – concludes Luisa Lopes.