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dewophile

07/28/16 11:57 PM

#202963 RE: mcbio #202959

I can't say for sure but many non steroidal FXR agonists have been described. I know GILD thinks their FXR agonist won't cause pruritis like OCA, so they at least think this SE is not tied to MOA / efficacy
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DewDiligence

07/29/16 9:26 PM

#202998 RE: mcbio #202959

ENTA's EDP-305 (FXR agonist) is not a bile acid, according to disclosures on recent CCs.