Replies to post #268005 on Avid Bioservices Inc (CDMO)

[eb0783]

Entdoc, no one has any because there are none (imo). With all due respect, I understand what you are thinking and implying. It is the same reason that dd called bavi a placebo; he saw no side effects and drew the conclusion that it is, therefore, a placebo. Imo (you may call it lightening striking) this is one time that there are no harmful side effects. If you remember, Dr Thorpe made it clear in 2005:

From the 2005 ASM transcript: Phillip Thorpe response to humans vs. animals question: “All animal species have the same regulation. What I haven’t explained is that PS is one in the same molecule in humans, mice, and all higher species. As far as we know, there is no difference in the regulation of these molecules between humans and other species. If you look in culture, it’s precisely the same.”

The phospholipids that they recognize have the same structure and cellular distribution in different mammalian species, simplifying the transition from experimental animals into humans. The antibodies are not toxic to mice, even when administered in high doses for prolonged periods of time.”

....at that dose we've never seen any sign of toxicity in mice or monkeys; about 14 species treated with the therapeutic dose. And that's thousands of mice monkeys. And even if you increase the dose to 10 mg/kg, that's 10x the therapeutic dose. So the conclusions with Tarvacin are that it has a unique mechanism of action, there's nothing else like it out there;

"it has a unique mechanism of action, there's nothing else like it out there;" .....unique, defined, "being the only one of its kind; unlike anything else." So it is understandable that most people have never seen anything like this..... = no side effects.

edit: THIS is also why some of us feel that bavi will continue to show results in humans parallel with what it has shown in animals. Hence, our high confidence of astronomical value. Both Thorpe ("And they were immune to the virus when reinfected with it," Thorpe said) and Brekken has shown that bavi cures animals and lets them die of old age even when re-infected. Shan said in 2006: "Based on the results reported today, the drug's anti-viral potential may be even more promising in humans than the animal models suggest."

[tradero]

From one the Oncologists who participated in Sunrise, the Bavi side effects were insignificant, very low toxicity...

Anyway, besides this feedback, the company had stressed this point in multiple ocasions. I dont see the reason for doubt