Did the Tarceva trials you cited have an SPA? If not, then comparing the p-value threshold of those trials to a trial such as GTOP’s that does have an SPA is apples vs oranges.
To obtain near assurance of FDA approval if the specified conditions are met, a sponsor seeking an SPA generally has to agree to more stringent requirements than what might be possible without an SPA.
Market Data 
Markets 
AI
