With Bavi immunotherapy combinations projected to double/triple ResponseRates (as per Dr. Brekken) presently seen in anti-PD-1 MAbs like Opdivo, Peregrine’s plan to run a variety of small phase1 trials by teaming up Bavituximab with AstraZeneca’s anti-PDL-1, Durvalumab, seems an excellent strategy for exploring a number of different cancer indications with an I-O combo, at a relatively low cost to PPHM.
CP, I’m thinking that if Dr. Garnick and company can pull the SUNRISE rabbit out of the hat with an FDA BLA stamp of approval, the DISRUPTION potential becomes an asset for Peregrine/Avid to employ, or not. Peregrine would hold the option. There are various geographical second and third world markets that won’t have access to I-O as soon as the first world will. Also I-O may not be affordable for some regions.
If a BP has been putting a sustained effort into slowing down Bavi plus chemo development over recent years, what do they have to do if Bavi plus Doce gets FDA approval for second line NSCLC???
Bavi plus Doce may produce 14 or 15 months overall survival in NSCLC, and have a better response rate and safety. That would look like a loose canon to BMY
There may be some double leverage here.
SUNRISE yields a BLA?
Bavi boosts downstream immunotherapies...
Not many options left for the BP(s) that could have their small response rate footprints in NSCLC I-O markets disrupted.
Or, don’t have Bavi available for I-O combinations in-house...
Who will own the IP???
Solution???
ASTRONOMICAL
IMO
sunstar
How many cancer indications are there?
Acute lymphoblastic leukemia (ALL)
Acute myeloid leukemia
Adrenocortical carcinoma
AIDS-related cancers
AIDS-related lymphoma
Anal cancer
Appendix cancer
Astrocytoma, childhood cerebellar or cerebral
Basal-cell carcinoma
Bile duct cancer, extrahepatic (see cholangiocarcinoma)
Bladder cancer
Bone tumor, osteosarcoma/malignant fibrous histiocytoma
Brainstem glioma
Brain cancer
Brain tumor, cerebellar astrocytoma
Brain tumor, cerebral astrocytoma/malignant glioma
Brain tumor, ependymoma
Brain tumor, medulloblastoma
Brain tumor, supratentorial primitive neuroectodermal tumors
Brain tumor, visual pathway and hypothalamic glioma
Breast cancer
Bronchial adenomas/carcinoids
Burkitt's lymphoma
Carcinoid tumor, childhood
Carcinoid tumor, gastrointestinal
Carcinoma of unknown primary
Central nervous system lymphoma, primary
Cerebellar astrocytoma, childhood
Cerebral astrocytoma/malignant glioma, childhood
Cervical cancer
Childhood cancers
Chondrosarcoma
Chronic lymphocytic leukemia
Chronic myelogenous leukemia
Chronic myeloproliferative disorders
Colon cancer
Cutaneous T-cell lymphoma
Desmoplastic small round cell tumor
Endometrial cancer
Ependymoma
Epitheliod Hemangioendothelioma (EHE)
Esophageal cancer
Ewing's sarcoma in the Ewing family of tumors
Extracranial germ cell tumor, childhood
Extragonadal germ cell tumor
Extrahepatic bile duct cancer
Eye cancer, intraocular melanoma
Eye cancer, retinoblastoma
Gallbladder cancer
Gastric (stomach) cancer
Gastrointestinal carcinoid tumor
Gastrointestinal stromal tumor (GIST)
Germ cell tumor: extracranial, extragonadal, or ovarian
Gestational trophoblastic tumor
Glioma of the brain stem
Glioma, childhood cerebral astrocytoma
Glioma, childhood visual pathway and hypothalamic
Gastric carcinoid
Hairy cell leukemia
Head and neck cancer
Heart cancer
Hepatocellular (liver) cancer
Hodgkin lymphoma
Hypopharyngeal cancer
Hypothalamic and visual pathway glioma, childhood
Intraocular melanoma
Islet cell carcinoma (endocrine pancreas)
Kaposi sarcoma
Kidney cancer (renal cell cancer)
Laryngeal cancer
Leukaemias
Leukaemia, acute lymphoblastic (also called acute lymphocytic leukaemia)
Leukaemia, acute myeloid (also called acute myelogenous leukemia)
Leukaemia, chronic lymphocytic (also called chronic lymphocytic leukemia)
Leukemia, chronic myelogenous (also called chronic myeloid leukemia)
Leukemia, hairy cell
Lip and oral cavity cancer
Liposarcoma
Liver cancer (primary)
Lung cancer, non-small cell
Lung cancer, small cell
Lymphomas
Lymphoma, AIDS-related
Lymphoma, Burkitt
Lymphoma, cutaneous T-Cell
Lymphoma, Hodgkin
Lymphomas, Non-Hodgkin (an old classification of all lymphomas except Hodgkin's)
Lymphoma, primary central nervous system
Macroglobulinemia, Waldenström
Male breast cancer
Malignant fibrous histiocytoma of bone/osteosarcoma
Medulloblastoma, childhood
Melanoma
Melanoma, intraocular (eye)
Merkel cell cancer
Mesothelioma, adult malignant
Mesothelioma, childhood
Metastatic squamous neck cancer with occult primary
Mouth cancer
Multiple endocrine neoplasia syndrome, childhood
Multiple myeloma/plasma cell neoplasm
Mycosis fungoides
Myelodysplastic syndromes
Myelodysplastic/myeloproliferative diseases
Myelogenous leukemia, chronic
Myeloid leukemia, adult acute
Myeloid leukemia, childhood acute
Myeloma, multiple (cancer of the bone-marrow)
Myeloproliferative disorders, chronic
Myxoma
Nasal cavity and paranasal sinus cancer
Nasopharyngeal carcinoma
Neuroblastoma
Non-Hodgkin lymphoma
Non-small cell lung cancer
Oligodendroglioma
Oral cancer
Oropharyngeal cancer
Osteosarcoma/malignant fibrous histiocytoma of bone
Ovarian cancer
Ovarian epithelial cancer (surface epithelial-stromal tumor)
Ovarian germ cell tumor
Ovarian low malignant potential tumor
Pancreatic cancer
Pancreatic cancer, islet cell
Paranasal sinus and nasal cavity cancer
Parathyroid cancer
Penile cancer
Pharyngeal cancer
Pheochromocytoma
Pineal astrocytoma
Pineal germinoma
Pineoblastoma and supratentorial primitive neuroectodermal tumors, childhood
Pituitary adenoma
Plasma cell neoplasia/Multiple myeloma
Pleuropulmonary blastoma
Primary central nervous system lymphoma
Prostate cancer
Rectal cancer
Renal cell carcinoma (kidney cancer)
Renal pelvis and ureter, transitional cell cancer
Retinoblastoma
Rhabdomyosarcoma, childhood
Salivary gland cancer
Sarcoma, Ewing family of tumors
Sarcoma, Kaposi
Sarcoma, soft tissue
Sarcoma, uterine
Sézary syndrome
Skin cancer (non-melanoma)
Skin cancer (melanoma)
Skin carcinoma, Merkel cell
Small cell lung cancer
Small intestine cancer
Soft tissue sarcoma
Squamous cell carcinoma – see skin cancer (non-melanoma)
Squamous neck cancer with occult primary, metastatic
Stomach cancer
Supratentorial primitive neuroectodermal tumor, childhood
T-Cell lymphoma, cutaneous – see Mycosis Fungoides and Sézary syndrome
Testicular cancer
Throat cancer
Thymoma, childhood
Thymoma and thymic carcinoma
Thyroid cancer
Thyroid cancer, childhood
Transitional cell cancer of the renal pelvis and ureter
Trophoblastic tumor, gestational
Unknown primary site, carcinoma of, adult
Unknown primary site, cancer of, childhood
Ureter and renal pelvis, transitional cell cancer
Urethral cancer
Uterine cancer, endometrial
Uterine sarcoma
Vaginal cancer
Visual pathway and hypothalamic glioma, childhood
Vulvar cancer
Waldenström macroglobulinemia
Wilms tumor (kidney cancer), childhood
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