Replies to post #146827 on Innovation Pharmaceuticals Inc (IPIX)

[ericseb2003]

That was my thinking too after a read of your original posting of those results, that the SCID model has flopped in ultimately predicting Psoriasis resolution in humans once before, so best we be somewhat dubious of its reliability in the Prurisol trial. Hope it pans out this time, but not perceiving it to be a slam dunk by any stretch.

As you're aware, model predictability in this industry is always challenging, I remember reading a top immunologist joking that he has cured (and killed) millions of mice in his lifetime. If only the jump to humans was seamless, we'd be a near immortal species.

[I Need Help]

Just something to think on: Purisol first got the attention of Menon while perusing papers on the side effects of an AIDS drug. The interesting effect, the drug seemed to have a correlation with psoriasis symptom improvement.

So, the correlation was further tested for in mice studies. And, the results supported the benefical correlations in an astonishing way.

The original AIDS drug, reformulated for psoriasis, named Purisol.

So, from humans, to mice, and now back to humans. Point being, Purisol effects initially were spotted in humans. Although, the first human observations needed further research and testing.

So, here we are. And, management remains confident. Never a sure bet with new drug testing; but, Purisol definitely a good bet.

[To infinity and beyond!]

Another strong effort- saves me form having to google failed psoriasis trials looking for lack of correlation of murine to human results. I actually did start this task, but it is annoying, and slow, and I am lazy.

In the long run does P even matter? It would be awfully nice to see the company take off sooner rather than later, and a deal for P would be so helpful for getting cash for other projects- like money for Mayo and pancreatic CA trial, just one example.

The stock will be driven by B in its various guises and by K, but so much of this benefit is a long way off that one is tempted to get hopes raised by P prospects. Let's say P fails- drop to a dollar likely, my guess. And then how long till it gets pulled back up? B-OM data a long way off- a year, maybe? None of the other drivers will have results for a couple of years. Most important are the phase 2's for K and that will be 2 years from now for results?

So if P fails there is a very long period where CTIX will have no catalysts, and it will be a real test. Something like a darkness before the dawn, whereas dawn could start early with Prurisol success. How daylight savings time impacts the earliness of dawn is not clear to me, in this instance.

A very long night ahead of us, or an early dawn, if one's mind runs toward light and darkness as metaphors.
I suppose considering the recent Boston weather I should have just stuck with rain and sun...