Replies to post #146633 on Innovation Pharmaceuticals Inc (IPIX)

[KMBJN]

Very interesting about IL-20. Thanks for the information showing this study from 2009.

I saw Novo-Nordisk's was developing an anti-IL-20 antibody fletikumab / NNC0109-0012 for RA, which didn't work out.

They have also completed a Phase I in psoriasis:

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134703

"The expansion phase was terminated early due to apparent lack of PASI improvement."

So, directly targeting IL-20 with an IL-20 antibody didn't seem to work for psoriasis (so far). It seems that Novo-Nordisk has dropped its development altogether - based on a brief glance at their pipeline from their website.

I wonder what GeorgeIJ would say about all these IL-20 results?

I didn't read the animal anti-IL-20 psoriasis data. Here's a promising pre-clinical anti-IL-20 effect in prostate cancer:

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139871

I guess these compounds need further study.

Does anybody know the mechanism by which Prurisol (abacavir) might have an effect on IL-20 cytokine production? Maybe it doesn't really matter, and IL-20 is a secondary effect correlating with reduced psoriasis, and not directly causative for psoriasis.