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revenue_monster

12/17/15 8:44 AM

#245940 RE: Protector #245938

Too funny more than double cost is to be taken at face value to be 50% sharing of costs. Nice one!

Steve King: The advantages are on several fronts. #1 is it really gives us the flexibility to run the study in the way we want to run the study & where we want to run it. Because otherwise, we’d have to source Nivo [Opdivo=nivolumab] or one of the other PD-1 inhibitors on a regional basis, in which the drug isn’t approved in lot of different regions where you may want to run the study. So just operationally, it gives us the freedom to more efficiently run a study and get it up & running much quicker than we otherwise would have able to. #2, it really gives us a great opportunity to potentially reduce the cost of what study otherwise would have been, because if we would have to go out and acquire the drug for a clinical study, it could as much as double the cost of the trial. So, it just all around allows us to run a much more efficient trial with the drug that’s in our discussions with the KOLs in the field, people with direct experience, they feel that the PD-L1 antibodies work at least as well as the anti-PD-1 antibodies. Our goal is to answer a key question, which is, “can bavituximab add to the activity of a PD-1/PD-L1 inhibitor?”, and this allows us doing on a timeframe. So, there are just a lot of huge advantages. I’ll end that with the fact that also we’re working with a what we think is a great partner [AstraZeneca]. They’ve been very interactive so far. They also have a lot of knowledge of PD-L1/PD-L1 status in the patients, which is one of the things we'll want to be looking at as part of both the Ph2 as well as in the other studies we run in NSCLC, as our ability to have a positive impact on potentially those PD-L1 negative tumors, which don’t typically response well the PD-1 therapy. That’s sort of one of those things that’s hard to put a numeric value to, but is a true advantage of working with a great partner.
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InternetForumUser

12/17/15 9:37 AM

#245949 RE: Protector #245938

it could as much as double the cost of the trial.

Unfortunately that statement is still somewhat vague; therefore, even if there was a cost savings it is not being reflected anywhere, well, unless the PPS being at $1.15 is a sign of the discount that PPHM received from AZN. As a matter of fact, if SK says it, it must be true and factual. How does does one do the math:

It Could + As Much - (Double * Cost of Trial) = Savings

Hmm, therefore, Savings = PUF

If there was a deal from a major BP of $2.5 BILLION of 55% of Peregrine with another $1.5 BILLION Guaranteed by 2018.. I am fairly certain, the PPS would be around $15-$20... But then again, why would anyone want a money grubbing deal like that one.

Peregrine owns 100% of the Pipeline that is worth $1.15/share and "it could" be worth more maybe even double by 2018 but that is no guarantee.


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cjgaddy

12/17/15 9:48 AM

#245951 RE: Protector #245938

SK 12-15-15/BioWorld on AZN: “We save probably as much as we're spending because of the cost of these drugs.”

12-15-15/BioWorld: “If You Can't Beat 'em, Join 'em; Looking for Immuno-onc Boost”
By Brian Orelli, BioWorld Staff Writer
...
Earlier this year, Peregrine partnered up with Astrazeneca to test the pharma's anti-PD-L1 immune checkpoint inhibitor, durvalumab, with bavituximab, after preclinical data suggested that the combination might help even if tumors don't initially express PD-L1. By removing the phosphatidylserine checkpoint, the immune system is activated, but the tumor can then use PD-L1 to inhibit the immune system. Durvalumab should help perpetuate the bavituximab-induced immune response, while boosting the opportunity for durvalumab in tumors that are not expressing PD-L1 until the bavituximab treatment. "It's sort of a win-win situation," King said. ...

King said he thinks that bavituximab will likely work with any of the drugs targeting the PD-1 pathway, but decided to work with London-based Astrazeneca rather than one of the FDA-approved drugs, in part, because Astrazeneca was willing to provide the drug free of charge. "We save probably as much as we're spending because of the cost of these drugs," King said.
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