Good post. Even tired from travel I can see the intended humour.
In Reply to 'ImmunoATX'
The hamster swishing comment was meant as a joke (presumably an obvious one).
I don't think anyone here is trying to quantitatively predict outcomes in humans based on results in rodent studies. I believe the sentiment by most on this board is that we are hopeful....hopeful that the patient's qualitative experience in the Ph2 B-OM are comparable to what was seen in the pre-clinical hamster study.
I will argue, however, that it is certainly reasonable to expect that the B-OM outcomes may be quantitatively similar to those seen in hamsters....otherwise, what's the point in declaring a rodent model as a gold standard for pre-clinical evaluation, if it isn't predictive of results in humans?!? Isn't that the purpose of having an animal model in the first place....because it is predictive??
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