Replies to post #225363 on Avid Bioservices Inc (CDMO)

[geocappy1]

Did they not recently release data from humans that showed similar reductions on these Cells?

[biopharm]

Though they have already proved that higher MDSC's do not lead to a good outcome and every patient should be asking their oncologist what they are doing to decrease those MDSC's...

Myeloid derived suppressor cells (MDSC) and their potent immune suppressive activity

MDSC in cancer

MDSC in chronic infections

MDSC during stress

MDSC in surgical trauma

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I'm sure they are keeping tabs on MDSC's in the melanoma trial and if it follows this pattern below, things may start heating up. Though, I'd say there must be lots of data sitting in some repository somewhere that proves that Dmitry Gabrilovich is correct in saying MDSC are predictors of clinical outcome in cancer. If I was a patient, I'd ask for my complete MDSC count/breakdown and ask what they are doing to decrease them....



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MDSC as predictors of clinical outcome in cancer:

Melanoma:

* Clinical responders to ipilimumab therapy showed significantly less MDSC as compared to non-responders. MDSC may be used as predictive marker of response

* Frequency of MDSC correlated with disease progression and decreased overall survival.

* ....
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