>Any idea of any systemic tox issues of this immunosuppressive in an elderly population? Some of the target indications (dry eye, AMD) are potentially chronic uses. Novartis oral cyclosporine is contraindicated for those with hypertension, would this also be?<
The devil is in the details of the formulation. Restasis from AGN is another version of cyclosporine, but AGN has been able to tweak the formulation to make the systemic effects essentially nil.
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