Frequently those with chronic pain will be prescribed a main prescription of ER tablets that they take daily. And for breakthrough pain they are prescribed much smaller doses of IR. Obviously the pharms charge by the mg so the $$ is in the ER. From my experience the IR's have always been easy to abuse (granted I haven't touched any oxys in ~4 years so I am not sure what is on the streets now a days).. The chemistry is sound, and so long as no Nal is released from ingestion there is no reason we will not pass PIII with flying colors. My only concern is how things will be handled after approval, which I think Nasarat is qualified to handle, but will it be widely adopted by the medical community is the question. Either way I plan to take some off the table after 200 is approved. I see plenty of opportunities here to make money short and long term.