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RockRat

03/05/15 1:44 AM

#188161 RE: jbog #188159

So much for the reports a few days ago that PCYC partner J&J was the prospective buyer. Anyone see a bidding war here?

Regards, RockRat
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DewDiligence

03/05/15 9:45 AM

#188167 RE: jbog #188159

ABBV-PCYC CC slides:

http://t.co/GjkC99R0yc
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caravon

03/05/15 10:01 AM

#188169 RE: jbog #188159

jbog wrote:

AbbVie Inc. said late Wednesday it will buy cancer biotech Pharmacyclics Inc. in a $21 billion deal... "Doesn't make a lot sense"



I am with you. Gonzalez is an absolute disaster for Abbv. $21B for less than a half in $1B-annual sale. WOW. GILD got Pharmacist for $11B with ~$16B+ annual HCV sale just for itself!

PS
Abbv could get Enanta for $1.5B (the amount of penalties Gonzales paid for his failed tax adventure).
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DewDiligence

04/17/15 12:21 PM

#190058 RE: jbog #188159

ABBV starts phase-1 trial of Imbruvica+ABT-199 in second-line MCL:

https://clinicaltrials.gov/ct2/show/NCT02419560

This is the kind of combination regimen that was an impetus for ABBV to pay so much for PCYC.

H/t @lomu_j.
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DewDiligence

05/15/15 5:10 PM

#191306 RE: jbog #188159

ABBV getting closer on PCYC tender offer, but it’s not quite there yet:

http://finance.yahoo.com/news/abbvie-extends-exchange-offer-acquire-204300468.html

AbbVie Inc. today announced that it has extended the expiration of its exchange offer to acquire all of the outstanding shares of common stock of Pharmacyclics, Inc. to 5 p.m., New York City time, on May 22, 2015.

The depositary of the exchange offer has advised that, as of 4:00 p.m., New York City time, on May 15, 2015, a total of approximately 42,822,941 shares of Pharmacyclics common stock were validly tendered and not properly withdrawn in the exchange offer.

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DewDiligence

09/14/15 9:32 AM

#194989 RE: jbog #188159

ABBV submits sNDA for Imbruvica in first-line CLL:

http://finance.yahoo.com/news/abbvie-announces-submission-supplemental-drug-123000267.html

Label expansion of Imbruvica was, of course, a major impetus for ABBV’s $21B acquisition of PCYC.
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DewDiligence

12/03/16 8:19 PM

#206595 RE: jbog #188159

Imbruvica shows impressive activity in CLL/SLL after 5 years:

http://finance.yahoo.com/news/data-ash-2016-show-strong-000500706.html

In these studies (PCYC-1102 and PCYC-1103), with five years of follow-up, the ORR in patients treated with IMBRUVICA was 89%, with 14% of patients achieving complete responses (CR) [87% ORR with 29% CR in TN patients (n=31) and 89% ORR with 10% CR in r/r patients (n=101)]. Median time on study was 62 months (1-67) for TN patients and 49 months (1-67) for r/r patients.

Overall survival (OS) at five years was 92% for TN patients and 57% for r/r patients, with a PFS rate of 92% and 43%, respectively. Median OS and median duration of response (DOR) was not reached. Median PFS was not reached in TN patients and was 52 months for r/r patients.

These are the kinds of results ABBV was hoping for when it acquired PCYC (and approximately half the worldwide Imbruvica economics) for $21B in 2015 (#msg-111425234).